Micky van de Ven Double Halts Everton's Run at Brand New Stadium
The Dutch defender emerged as the first backline player to net two goals in a Premier League game for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven heads home twice in first half
The home side's Jake O'Brien has equalizer disallowed after video check
Senegalese midfielder nets third in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender scored on two occasions as Tottenham prolonged their winning streak in away games in the Premier League and delivered the Toffees their first defeat at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at the dockside location, having departed their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the first half to put their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a third to seal the victory.
Jake O'Brien believed he had equalized the scores a short while after the defender's first goal, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a number of chances, while the Italian goalkeeper made a succession of fine stops to guarantee the London club went five matches on the road unbeaten in the Premier League.
But the video assistant referee stepped in, instructing the match official to check the score on the screen and the official ruled that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's team into third place in the division, a handful of points off local foes and table-toppers the Gunners.
Everton stay in 14th position and are six points ahead of the drop zone.
Tottenham analysis: The defender excels in role at each end of the field
Following a uninspiring weekday performance in the Champions League against the French side, where they managed a mere two shots on target, the manager chose Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur directing the ball toward the six-yard box for an free the defender to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his second in first-half stoppage time as he rose above the England keeper to nod in.
Van de Ven was equally impressive in defensive duties, partnering effectively with his defensive colleague as the duo handled superbly with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees lacking striker's instinct
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters flocked to the gates after Sarr's final goal for Spurs.
The break in the team's unbeaten home run will not be a massive worry for the manager, but their attacking woes are.
The forward and Thierno Barry - the Toffees' two recognised strikers - had netted just one league goal between them before the weekend's match.
And they were unable to contribute to that poor record on a wet and gloomy night on Merseyside.
The striker's form was summed up when he chose to overhead kick a golden opportunity from near the goal, even with having space and opportunity to reposition for a more conventional attempt that would have challenged Vicario.
Barry, as well, failed to make an impact after coming on for the starter in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's attacks came through Grealish and Ndiaye, who tirelessly whipped threatening crosses into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their fourth-round Carabao Cup tie against the Magpies.